Blood pressure changes during pregnancy in relation to urinary paraben, triclosan and benzophenone concentrations: A repeated measures study
| Autor: | Yang Peng, Cheng Hu, Shunqing Xu, Hongxiu Liu, Zongwei Cai, Yuanyuan Li, Yangqian Jiang, Xiaojie Sun, Wei Xia, Bin Zhang, Hongzhi Zhao, Yanqiu Zhou, Jing Fang, Jiufeng Li, Wenyu Liu |
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| Rok vydání: | 2019 |
| Předmět: |
China
010504 meteorology & atmospheric sciences Urinary system Parabens Physiology Blood Pressure Urine 010501 environmental sciences 01 natural sciences Benzophenones chemistry.chemical_compound Pregnancy Humans Medicine Prospective Studies Prospective cohort study lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Fetus business.industry medicine.disease Triclosan Paraben Blood pressure chemistry Maternal Exposure Female business |
| Zdroj: | Environment International, Vol 122, Iss, Pp 185-192 (2019) |
| ISSN: | 0160-4120 |
| Popis: | Previous studies have proven the endocrine-disrupting properties and health hazards of parabens, triclosan, and benzophenones, but their relationship with blood pressure during pregnancy remains unknown. Therefore, we investigated the associations of repeated measures of urinary parabens, triclosan, and benzophenones with blood pressure during pregnancy and evaluated whether the associations were modified by fetal sex. From a prospective birth cohort in Wuhan, China, we collected urine samples from 644 pregnant women in the first, second, and third trimesters between 2014 and 2015. Five parabens, triclosan, and three benzophenones were quantified in all urine samples. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured in each trimester after urine sampling. Mixed linear models were used to estimate the associations between urinary chemical levels and blood pressure during pregnancy among all pregnant women and subgroups stratified by fetal sex. In the women carrying male fetuses, urinary triclosan and selected benzophenone concentrations were associated with a slight change of SBP during pregnancy. In the women carrying female fetuses, no chemical was associated with SBP, while urinary concentration of triclosan was inversely associated with DBP, though the magnitude was small. Urinary paraben levels weren't associated with blood pressure during pregnancy. Our results suggest that triclosan and selected benzophenone exposure might be associated with blood pressure during pregnancy in a potential fetal sex-different manner. Replicated research studies in pregnant women with higher triclosan and benzophenone exposure levels are needed in the future. |
| Databáze: | OpenAIRE |
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