Prevalence and Prognostic Value of HPV among Tunisian Patients with Laryngeal Cancer and Relationship between DNA HPV and p16, IGF-1R, Survivin, p53 Expressions
| Autor: | Ahmed El May, Mariem Ben Elhadj, Olfa El Amine, Asma Fourati, Nehla Mokni Baizig, Michèle-Veronique El May, Aida Goucha |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology medicine.medical_specialty Prognostic factor Tunisia Laryngeal Cancers Survivin Receptor IGF Type 1 Internal medicine Prevalence medicine Humans Risk factor Laryngeal Neoplasms Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Aged 80 and over Human papilloma virus business.industry Papillomavirus Infections Cancer General Medicine Middle Aged Prognosis medicine.disease Survival Rate Otorhinolaryngology DNA Viral Etiology Female Tumor Suppressor Protein p53 business |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 129:863-871 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/0003489420918280 |
| Popis: | Objectives: Tobacco and alcohol are the main etiological factors common to laryngeal cancers. However, the Human Papilloma Virus (HPV) constitutes an alternative risk factor according to several studies. In Tunisia, despite the annual increasing incidence of laryngeal squamous cell carcinoma (LSCC), the prevalence and prognostic significance of HPV have never been explored. In this study, we sought to highlight HPV DNA in 70 biopsies of laryngeal cancer, and to analyze the status of HPV infection in association with p53, p16, survivin, and IGF-1R expressions. Methods: HPV high risk (HPV HR) DNA was detected in tumors by in situ hybridization. However, the expression of p53, p16, survivin and IGF-1R were stained by immunohistochemistry test. The correlations of HPV status with clinicopathological parameters, overall survival, disease-free survival and proteins expressions were statistically evaluated. Results: HPV HR DNA was detected in 39 out of 70 (55.71%) laryngeal tumors. HPV+ patients have a better overall survival ( P = .081) and long disease-free-survival ( P = .016) with a low rate of recurrence ( P = .006) than HPV– patients. No significant correlations were found between HPV HR status and clinicopathological parameters (all P > .005). Moreover, HPV+ tumors were not associated with expression of p53, p16 and survivin. However, HPV HR status correlates with weak to moderate IGF-1R expression ( P = .043). Conclusion: The substantial detection of HPV HR in LSCC tumors suggest that this virus plays an important part in laryngeal cancer in Tunisia. It is a good prognostic factor. In addition, HPV infection could act to block the pathway of IGF-1R expression. |
| Databáze: | OpenAIRE |
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