Decreased heterotopic osteogenesis in vitamin-D-deficient, but normocalcemic guinea pigs
| Autor: | Mitsuo Yamauchi, Agna Boass, Anna Dziedzic-Goclawska, Svein U. Toverud, Artur Kaminski |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Transplantation Heterotopic Calcitriol Guinea Pigs Urinary Bladder Biochemistry vitamin D deficiency Epithelium Phosphates Endocrinology Calcification Physiologic Osteogenesis Internal medicine Vitamin D and neurology Medicine Animals Bone growth Tibia business.industry Mesenchymal stem cell medicine.disease Alkaline Phosphatase Vitamin D Deficiency Transplantation medicine.anatomical_structure Tissue Transplantation Surgery Calcium Bone marrow business Calcification medicine.drug |
| Zdroj: | Bone and mineral. 19(2) |
| ISSN: | 0169-6009 |
| Popis: | The effect of vitamin D deficiency unhampered by hypocalcemia on de novo bone formation was studied in guinea pigs. Heterotopic induction of osteogenesis was evaluated 4 weeks after intramuscular transplantation of allogenic urinary bladder transitional epithelium from vitamin-D-repleted (+D) donors into +D and -D recipients. In -D recipients the frequency of osteogenesis and the amount of induced bone were significantly diminished; induced bone was less mature, scantly cellular woven bone poorly repopulated with bone marrow. No effect of vitamin D deficiency on orthotopic bone growth and on mineralization of orthotopic and heterotopically induced bone was observed. It is proposed that in addition to inducing factors (BMPs, growth factors) which may be responsible for transformation of mesenchymal cells to osteoprogenitor cells, normal concentrations of 1,25-(OH)2D3 may be required for proliferation and further differentiation of these cells into osteoblasts and for expression of genes engaged in extracellular matrix formation and maturation. |
| Databáze: | OpenAIRE |
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