Translocations of fodrin and its binding proteins
| Autor: | Mark Willard, Celia Baitinger, Richard E Cheney |
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| Rok vydání: | 1987 |
| Předmět: |
Population
Guinea Pigs Biology Synaptic vesicle Nervous System Mice Myosin Ankyrin Animals Humans Spectrin Immunologic Capping education Actin chemistry.chemical_classification education.field_of_study General Neuroscience Microfilament Proteins Synapsin Cell biology stomatognathic diseases nervous system chemistry Axoplasmic transport Rabbits Carrier Proteins |
| Zdroj: | Brain research bulletin. 18(6) |
| ISSN: | 0361-9230 |
| Popis: | Fodrin, a protein related to erythrocyte spectrin, redistributes within the cell in certain situations. We compare such movements of fodrin and several fodrin binding proteins during the processes of axonal transport in neurons, and capping of surface proteins in lymphocytes. In neurons, three different populations of newly synthesized fodrin appear to be transported down the axons at different velocities corresponding to those of groups of transported proteins designated II, IV, and V. Actin, which can interact with fodrin, is transported at the velocity of group IV. Synapsin, a component of synaptic vesicles, is also reported to bind to fodrin. One population of synapsin is transported more rapidly than fodrin, at the velocity of group I; two additional populations of transported synapsin may overlap fodrin in groups II and IV. We consider possible functional associations of these different populations of fodrin and fodrin binding proteins. We note that the transport of group IV proteins resembles in certain respects the process of capping in lymphocytes, suggesting the possibility of a common mechanism. We outline one of several possible mechanisms. |
| Databáze: | OpenAIRE |
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