Comparison of the Effects of Prophylactic Antibiotic Therapy and Cost-effectiveness between Cefazolin (CEZ) and Sulbactam/Ampicillin (SBT/ABPC) in Gastric Cancer Surgery Employing Clinical Pathway
| Autor: | Ayumi Kato, Kenji Nishizawa, Kazuyoshi Honjo, Shizuka Soh, Teruo Kiyama, Toshiro Yoshiyuki, Yuya Ise, Makoto Shiragami, Masaaki Hirano, Setsuo Saitoh, Miwako Kamei, Kyoko Mitsuhashi, Shirou Katayama, Ken Hagiwara |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Cost-Benefit Analysis Antibiotics Cefazolin Pharmaceutical Science Postoperative Complications Pharmacotherapy Gastrectomy Stomach Neoplasms Ampicillin Internal medicine medicine Humans Gram-Positive Bacterial Infections Aged Retrospective Studies Pharmacology business.industry Cancer Sulbactam Antibiotic Prophylaxis Middle Aged medicine.disease Surgery Systemic inflammatory response syndrome Critical Pathways Female Complication business medicine.drug |
| Zdroj: | YAKUGAKU ZASSHI. 124:815-824 |
| ISSN: | 1347-5231 0031-6903 |
| DOI: | 10.1248/yakushi.124.815 |
| Popis: | The present study was designed to investigate the effects of prophylactic antibiotic therapy and the cost-effectiveness of Cefazolin (CEZ) and Sulbactam/Ampicillin (SBT/ABPC) in gastric cancer surgery employing clinical pathway. 157 patients (62 in the CEZ group and 95 in the SBT/ABPC group), who underwent surgery for gastric cancer at the First Department of Surgery of our hospital, were investigated. There was no significant difference between the groups with regard to sex, age, incidence of complication, stage of cancer, surgical method, operative time and blood loss, length of hospitalization, the appearance of systemic inflammatory response syndrome (SIRS), changes body temperature, white blood cell count (WBC), C-reactive protein (CRP), or clinical outcome of postoperative care by a nurse during post-operation for 7 days. The prophylactic effect of infection was also no different between the CEZ (69.4%) and SBT/ABPC (69.5%) groups. In contrast, decision analysis strongly indicated that the anticipate cost of antibiotics was higher in the latter group (yen 20402) than in the CEZ group (yen 15556), suggesting that the prophylactic effect of CEZ may be more cost-effective. Thus, evaluations of pharmacotherapy from the aspect of cost may be one of the important responsibility of hospital pharmacists in the future. |
| Databáze: | OpenAIRE |
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