Liver transplantation is an alternative treatment of hepatocellular carcinoma beyond the Milan criteria
| Autor: | Chi-Hong Chu, Hsiu-Lung Fan, Teng-Wei Chen, Chung-Bao Hsieh, Hsiang-Chun Jan, Chan De-Chuan, Jyh-Cherng Yu, Sheng-Chuan His |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment education Liver transplantation Milan criteria Gastroenterology Young Adult Internal medicine medicine Carcinoma Hepatectomy Humans Survival analysis Aged Retrospective Studies Aged 80 and over business.industry Patient Selection Liver Neoplasms Retrospective cohort study General Medicine Middle Aged medicine.disease Liver Transplantation Treatment Outcome Hepatocellular carcinoma Surgery Female business Liver cancer |
| Zdroj: | American journal of surgery. 200(2) |
| ISSN: | 1879-1883 |
| Popis: | BACKGROUND: The decision to perform liver transplantation (LT) or liver resection (LR) for patients with hepatocellular carcinoma (HCC) who are beyond the Milan criteria remains controversial. METHODS: We retrospectively analyzed outcome data for 179 patients with HCC beyond the Milan criteria who were treated with LR (n = 135) or LT (n = 44). Univariate and multivariate Cox proportional hazard models were established. Kaplan-Meier survival curves were generated, and a log-rank test was performed to compare group survival status. RESULTS: Patients who underwent LR group were significantly older, had a lower TNM stage, and were more likely to have unilateral disease and noncirrhotic liver. Significantly more patients in the LR group had recurrence (53.3% vs 29.5%) or died (61.5% vs 43.2%) than patients in the LT group. Recurrence-free survival rates were 11.9% for the LR group and 61.5% for the LT group. The median overall survival duration showed no statistically difference between the LR group (28.0 months) and the LT group (50.0 months). CONCLUSIONS: LT may be the better choice for patients with HCC beyond the Milan criteria. |
| Databáze: | OpenAIRE |
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