The reticent tautomer: exploiting the interesting multisite and multitype reactivity of 4-pyrrolin-2-ones

Autor:	Tamsyn Montagnon, Georgios Vassilikogiannakis, Dimitris Kalaitzakis, Manolis Sofiadis
Rok vydání:	2020
Předmět:	Cascade reaction 010405 organic chemistry Chemistry Organic Chemistry Reactivity (chemistry) Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Tautomer 0104 chemical sciences
Zdroj:	Organic & Biomolecular Chemistry. 18:180-190
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c9ob02471a
Popis:	4-Pyrrolin-2-ones are a lesser known tautomeric relative of the 3-pyrrolin-2-ones. Despite their infrequent appearance in the literature, they are very interesting and useful compounds. They have highly controllable, multisite and multitype reactivities which are covered in this review. The applications of these transformations show how the 4-pyrrolin-2-ones make excellent intermediates en-route to a range of key alkaloids. Innovative, fast and adaptable syntheses of the 4-pyrrolin-2-ones and their onward use via cascade reaction sequences are also presented to complete the case for commending these compounds as highly versatile and valuable synthetic building blocks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526700c1bf6d38b52326c57bf87dc1d6 https://doi.org/10.1039/c9ob02471a Zobrazit plný text záznamu