Dietary restriction, mitochondrial function and aging: from yeast to humans
Autor: | Antoni Barrientos, Andrea Ruetenik |
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Jazyk: | angličtina |
Předmět: |
Aging
media_common.quotation_subject Dietary restriction Longevity Biophysics Oxidative phosphorylation Saccharomyces cerevisiae Mitochondrion Biology Mechanistic Target of Rapamycin Complex 1 medicine.disease_cause Biochemistry Article 03 medical and health sciences 0302 clinical medicine medicine Humans Sirtuins 030304 developmental biology media_common Caloric Restriction Genetics 0303 health sciences TOR Serine-Threonine Kinases Adenylate Kinase Cell Biology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha OXPHOS Cell biology Mitochondria TORC1 Mitochondrial biogenesis Multiprotein Complexes 030217 neurology & neurosurgery Function (biology) Oxidative stress Signal Transduction Transcription Factors |
Zdroj: | Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11):1434-1447 |
ISSN: | 0005-2728 |
DOI: | 10.1016/j.bbabio.2015.05.005 |
Popis: | Dietary restriction (DR) attenuates many detrimental effects of aging and consequently promotes health and increases longevity across organisms. While over the last 15 years extensive research has been devoted towards understanding the biology of aging, the precise mechanistic aspects of DR are yet to be settled. Abundant experimental evidence indicates that the DR effect on stimulating health impinges several metabolic and stress-resistance pathways. Downstream effects of these pathways include a reduction in cellular damage induced by oxidative stress, enhanced efficiency of mitochondrial functions and maintenance of mitochondrial dynamics and quality control, thereby attenuating age-related declines in mitochondrial function. However, the literature also accumulates conflicting evidence regarding how DR ameliorates mitochondrial performance and whether that is enough to slow age-dependent cellular and organismal deterioration. Here, we will summarize the current knowledge about how and to which extent the influence of different DR regimes on mitochondrial biogenesis and function contribute to postpone the detrimental effects of aging on healthspan and lifespan. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. |
Databáze: | OpenAIRE |
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