Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures
| Autor: | Seiji Inoue, Hiroe Yano, Mitsuhiro Ohta, Kiyoshi Ikeda, Kaori Matsumoto, Misao Toyomoto, Kyozo Hayashi, Kohji Okumura |
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| Rok vydání: | 2004 |
| Předmět: |
Nervous system
medicine.medical_specialty Prostaglandin Central nervous system Biophysics Biology Biochemistry Neuroprotection Dinoprostone chemistry.chemical_compound Mice Structural Biology Neurotrophic factors Internal medicine Nerve Growth Factor Genetics medicine Animals Secretion Molecular Biology Cells Cultured Prostaglandin D2 Brain-Derived Neurotrophic Factor Cell Biology Endocrinology medicine.anatomical_structure Nerve growth factor chemistry nervous system Astrocytes biology.protein lipids (amino acids peptides and proteins) Neurotrophin Astrocyte |
| Zdroj: | FEBS letters. 562(1-3) |
| ISSN: | 0014-5793 |
| Popis: | We found that prostaglandin (PG) D(2) and PGE(2), which are major PGs in the brain of mammals, powerfully induced the secretion of nerve growth factor (NGF) from cultured mouse astrocytes; PGE(2) or PGD(2) induced an approximately 12- or 19-fold increase in NGF secretion after a 24-h incubation, respectively. Moreover, it was found that the sequential metabolites of PGD(2), PGJ(2), Delta(12)-PGJ(2), and 15-deoxy-Delta(12,14)-PGJ(2), induced the NGF secretion to the culture medium strikingly (60-98-fold of the control after a 24-h incubation). NGF secretion induced by the J(2) series of PGs was accompanied by the increased expression of NGF mRNA. These PGs also stimulated the secretion/synthesis of brain-derived neurotrophic factor (BDNF). Our findings suggest that PGs play a neuroprotective role by inducing NGF and BDNF production in the central nervous system. |
| Databáze: | OpenAIRE |
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