Zinc inhibition of electron transfer: mechanism of beta receptor inhibition?
| Autor: | J M Gerrard, D A Peterson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology Adrenergic receptor GTP' Physiology Biochemistry (medical) Clinical Biochemistry chemistry.chemical_element Adenylate kinase Stimulation Cell Biology Zinc 030204 cardiovascular system & hematology Biochemistry Cyclase 03 medical and health sciences Electron transfer 0302 clinical medicine chemistry Biophysics Receptor |
| Zdroj: | Redox report : communications in free radical research. 1(4) |
| ISSN: | 1351-0002 |
| Popis: | Zinc has been shown to inhibit β-receptor activation of adenylate cyclase at a post receptor site. We have postulated that the β-receptor is one of several receptors activated by reduction, followed by transmembrane elector transfer accelerated by GTP. GTP accelerates electron transfer in a model system and this accelerated electron transfer is inhibited by zinc. This could explain the mechanism of the post receptor inhibition by zinc of the adenylate cyclase stimulation which follows β-receptor activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|