Hydrophilic and lipophilic moisturizers have similar penetration profiles but different effects on SC water distributionin vivo
| Autor: | Stan Pavel, Johann W. Wiechers, Gert S. Gooris, Joke A. Bouwstra, E. Rozema, Julia Caussin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Skin Absorption medicine.medical_treatment Dermatology Administration Cutaneous Biochemistry Permeability Body Water In vivo Spectroscopy Fourier Transform Infrared Dry skin Stratum corneum medicine Humans Solubility Skin pathology Molecular Biology Skin Chromatography Emollients Chemistry Water Single application Penetration (firestop) medicine.anatomical_structure Drug Design Female Moisturizer medicine.symptom |
| Zdroj: | Experimental Dermatology. 18:954-961 |
| ISSN: | 1600-0625 0906-6705 |
| DOI: | 10.1111/j.1600-0625.2009.00881.x |
| Popis: | Dry skin is often treated with hydrophilic and/or lipophilic moisturizers. Hydrophilic moisturizers must penetrate the stratum corneum (SC) deeply to function properly, whereas lipophilic moisturizers should remain in the upper SC layers. In this study, both types of moisturizers were applied on volunteers for 3 h, after which the relative amount of moisturizer and the water distribution in the SC were determined using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy in combination with tape-stripping. The results show that while hydrophilic moisturizers penetrate much more readily than lipophilic moisturizers, the latter are abundantly present in the upper regions of the SC. It was also observed that a 3-h treatment with lipophilic moisturizer did not result in increased water levels in the SC, whereas hydrophilic moisturizers retained water where they are located. The results suggest that upon prolonged application, adequate amounts of moisturizer can be obtained in those regions where they may cause moisturization in the central part of the SC. However, a single application of 3 h is probably too short to exert increased hydration as measured with ATR-FTIR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|