Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease
| Autor: | Pragyan Singh, Biswadip Das, Sunirmal Paira, Upasana Saha |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Saccharomyces cerevisiae Proteins Transcription Genetic Exosome complex Saccharomyces cerevisiae Biology Exosomes Exosome 03 medical and health sciences Structural Biology Transcription (biology) Humans Prospective Studies RNA Messenger Molecular Biology Gene Cell Nucleus Yeast mRNA surveillance Cell biology 030104 developmental biology Ribonucleoproteins Organ Specificity Mutation Exosome Multienzyme Ribonuclease Complex Biogenesis |
| Zdroj: | Journal of molecular biology. 430(14) |
| ISSN: | 1089-8638 |
| Popis: | Production of export-competent mRNAs involves transcription and a series of dynamic processing and modification events of pre-messenger RNAs in the nucleus. Mutations in the genes encoding the transcription and mRNP processing machinery and the complexities involved in the biogenesis events lead to the formation of aberrant messages. These faulty transcripts are promptly eliminated by the nuclear RNA exosome and its cofactors to safeguard the cells and organisms from genetic catastrophe. Mutations in the components of the core nuclear exosome and its cofactors lead to the tissue-specific dysfunction of exosomal activities, which are linked to diverse human diseases and disorders. In this article, we examine the structure and function of both the yeast and human RNA exosome complex and its cofactors, discuss the nature of the various altered amino acid residues implicated in these diseases with the speculative mechanisms of the mutation-induced disorders and project the frontier and prospective avenues of the future research in this field. |
| Databáze: | OpenAIRE |
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