Human Leukocyte Antigen May Predict Outcome of Primary Recurrent Spontaneous Abortion Treated with Paternal Lymphocyte Alloimmunization Therapy
| Autor: | Hirohiko Watanabe, Yutaka Maeda, Takahide Mori, Eri Kikkawa, Akinori Kimura, Megumi Takahashi, Taeko K. Naruse, Masako Furudono, Takashi Kano, Hironobu Ishikawa, Takayuki Warita, Makoto Onizuka, Hidetoshi Inoko |
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| Rok vydání: | 2007 |
| Předmět: |
Abortion
Habitual Lymphocyte Immunology Promoter polymorphism HLA-C Antigens Human leukocyte antigen Abortion Gene Frequency HLA Antigens Pregnancy HLA-G Humans Immunology and Allergy Medicine Genetic Predisposition to Disease Typing reproductive and urinary physiology HLA-G Antigens Polymorphism Genetic HLA-A Antigens business.industry Patient Selection Histocompatibility Antigens Class I Aborted Fetus Haplotype Obstetrics and Gynecology HLA-DR Antigens Treatment Outcome medicine.anatomical_structure Haplotypes Reproductive Medicine HLA-B Antigens Lymphocyte Transfusion Female business Live Birth HLA-DRB1 Chains |
| Zdroj: | American Journal of Reproductive Immunology. 58:383-387 |
| ISSN: | 1600-0897 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2007.00517.x |
| Popis: | Problem Recurrent spontaneous abortion (RSA) is defined by at least three consecutive abortions in otherwise healthy couples. Paternal lymphocyte alloimmunization therapy (PLAT) is an effective therapy for RSA in some cases, but there are no predictive markers about the effectiveness of PLAT. Method of study Forty-two consecutive cases with primary RSA treated by PLAT and 23 controls were the subjects. Polymorphisms of human leukocyte antigen (HLA)-E, HLA-G, HLA-A, HLA-B, HLA-C and HLA-DRB1 were investigated by sequenced based typing. Promoter polymorphism and a 14 bp ins/del polymorphism in exon 8 were also investigated for HLA-G. Results Thirty-eight RSA wives became pregnant within 1 year after PLAT. Among them, 27 obtained babies (succeeded PLAT cases), while 11 again aborted with no detectable chromosomal abnormalities in the aborted fetuses (aborted PLAT cases). The frequencies of HLA-G*010401, A*2402, B*5201, and DRB1*1502 were significantly increased in the aborted cases than those in the succeeded cases or controls. Of note, HLA-G*010401 was found in all aborted cases whereas it was found in 51.9% of succeeded cases (odds ratio = 21.4, P = 0.006, Pc = 0.03), and the presence of HLA-G*010401 could predict the abortion after PLAT with sensitivity and specificity of 100% and 48.1%, respectively. Conclusion Human leukocyte antigen testing may be useful for predicting effectiveness of PLAT in RSA. |
| Databáze: | OpenAIRE |
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