Remnant kidney hypermetabolism and progression of chronic renal failure
| Autor: | L. Chan, D. C. H. Harris, Robert W. Schrier |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment Renal function Nephron Biology Kidney Phosphates Oxygen Consumption Internal medicine medicine Animals Renal sodium reabsorption Kidney metabolism Rats Inbred Strains Nephrectomy Rats Perfusion Disease Models Animal medicine.anatomical_structure Endocrinology Verapamil Hypermetabolism Kidney Failure Chronic medicine.drug |
| Zdroj: | American Journal of Physiology-Renal Physiology. 254:F267-F276 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.1988.254.2.f267 |
| Popis: | To investigate the mechanisms whereby verapamil and dietary phosphate restriction slow progression of nephron loss after renal ablation, the effects of these maneuvers on inulin clearance (CIn), net sodium reabsorption (TNa+), oxygen consumption (QO2), and net glucose production (GP) were examined in isolated perfused normal and remnant kidneys. Preliminary studies characterized the isolated perfused remnant kidney perfusion. Adaptation to renal ablation was greater for QO2 (102% of normal), GP (138%), and kidney weight (79%) than CIn (51%) or TNa+ (40%). Verapamil (50 microM) lowered QO2 in remnant kidneys (1.64 +/- 0.24 vs. control 2.86 +/- 0.16 mumol.min-1.g-1, P less than 0.005), as did phosphate restriction (1.81 +/- 0.22 vs. control 3.05 +/- 0.40 mumol.min-1.g-1, P less than 0.05). These effects could not be accounted for by changes in CIn, TNa+, or GP and were not observed in normal kidneys. In summary 1) remnant kidneys are hypermetabolic compared with normal kidneys when assessed by QO2 and GP; 2) verapamil and phosphate restriction diminish the enhanced metabolic activity of remnant kidneys, an effect that is independent of TNa+; and thus 3) verapamil and phosphate restriction may slow progression of renal disease, at least in part by reducing renal metabolic demands. |
| Databáze: | OpenAIRE |
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