The seed oil of Paeonia ludlowii ameliorates Aβ25‐35‐induced Alzheimer's disease in rats
Autor: | Benxia Yu, Cai Hao, Xiu Yin, Zhihua Liao, Yuan-Jiang Xu, Chao-Qi Zhang, Lianqiang Li, Zhang Erhao, Yan-Jie Su, Ya-Jing Xing, Yazhou Lu, Fang Yuan, Xiaozhong Lan, Hong Quan |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Amyloid beta Morris water navigation task Biology Pharmacology Hippocampal formation Neuroprotection Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Paeonia ludlowii Hippocampus (mythology) neuronal damage TX341-641 cognitive function Nutrition. Foods and food supply apoptosis Paeonia ludlowii seed oil Alzheimer's disease biology.organism_classification Acetylcholinesterase 030104 developmental biology chemistry biology.protein 030217 neurology & neurosurgery Food Science |
Zdroj: | Food Science & Nutrition, Vol 9, Iss 5, Pp 2402-2413 (2021) |
ISSN: | 2048-7177 |
Popis: | Paeonia ludlowii, a plant of the Paeoniaceae family, has abundant genetic diversity in different populations, and the seed oil can be used in a diverse number of activities. However, its neuroprotective effect is not clear. We investigated the memory‐improving effects and associated mechanisms of Paeonia ludlowii seed oil (PLSO) on amyloid beta (Aβ)25–35‐induced Alzheimer's disease (AD) in rats. The Morris water maze test was undertaken, and subsequently, the content of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and acetylcholinesterase (ACHE) in the hippocampus was detected by biochemical analyses. To further study PLSO, we examined the pathologic structure and apoptosis of hippocampal tissue by staining. Immunohistochemical analysis was used to detect expression of IBA‐1 and GFAP in the hippocampus. Detection of proinflammatory factors was achieved by reverse transcription–quantitative polymerase chain reaction and Western blotting. High‐dose PLSO inhibited expression of GFAP and IBA‐1. We demonstrated that high‐dose PLSO can regulate activation of glial cells and mediate apoptosis of hippocampal cells, and significantly improve learning and memory deficits in AD rats. PLSO could be developed as a nutritional supplement and sold as a drug for AD prevention and/or treatment. |
Databáze: | OpenAIRE |
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