Pharmacokinetics of intravenous amoxycillin and potassium clavulanate in seriously ill children
| Autor: | N.D. Barnes, T. C. G. Tasker, Robert L. Horton, A. Elias Jones |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Potassium Antibiotics chemistry.chemical_element Pharmacology Clavulanic Acids Pharmacokinetics Potassium Clavulanate Clavulanic acid polycyclic compounds medicine Humans Pharmacology (medical) Child Clavulanic Acid Chemotherapy business.industry Half-life Amoxicillin Bacterial Infections Surgery Infectious Diseases chemistry Child Preschool Injections Intravenous Female business medicine.drug Half-Life |
| Zdroj: | The Journal of antimicrobial chemotherapy. 25(2) |
| ISSN: | 0305-7453 |
| Popis: | The pharmacokinetics of amoxycillin and potassium clavulanate were studied in 15 sick children after a 30 min iv infusion of 50 mg/kg amoxycillin and 5 mg/kg clavulanic acid as the potassium salt. Levels of both compounds in plasma were assayed microbiologically. Mean peak concentrations at the end of the infusion were 121.0 mg/l of amoxycillin and 12.0 mg/l of clavulanate, falling to a mean of 15.8 and 1.92 mg/l respectively after 2 h. Mean beta phase T 1/2 was 0.88 h for amoxycillin and 0.79 h for clavulanate. The elimination half-life of clavulanate in some individuals was much shorter because of higher plasma clearance. The data suggest that the treatment of some infections due to beta-lactamase producing organisms in such severely ill children may require more frequent iv administration of amoxycillin and potassium clavulanate, than in less severely affected children. |
| Databáze: | OpenAIRE |
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