Cytokines in cancer drug resistance: Cues to new therapeutic strategies
| Autor: | Ren Yu Huang, Zhe-Sheng Chen, Li Pai Chen, Valerie Sloane Jones, Li-Wu Fu, Ruo Pan Huang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Cancer Research Stromal cell medicine.medical_treatment media_common.quotation_subject Multiplex immunoassay Drug resistance Bioinformatics 03 medical and health sciences 0302 clinical medicine Antibody array Neoplasms Genetics medicine Humans Cytokine media_common Tumor microenvironment Mechanism (biology) business.industry Cancer Cancer drug resistance medicine.disease 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Immunology Cytokines Stromal Cells business |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1865:255-265 |
| ISSN: | 0304-419X |
| Popis: | The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the war against cancer. However, cancers do not give up without a fight. They may develop multiple mechanisms of drug resistance, including apoptosis inhibition, drug expulsion, and increased proliferation that reduce the effectiveness of the drug. The collective work of researchers has highlighted the role of cytokines in the mechanisms of cancer drug resistance, as well as in cancer cell progression. Furthermore, recent studies have described how specific cytokines secreted by cancer stromal cells confer resistance to chemotherapeutic treatments. In order to gain a better understanding of mechanism of cancer drug resistance and a prediction of treatment outcome, it is imperative that correlations are established between global cytokine profiles and cancer drug resistance. Here we discuss the recent discoveries in this field of research and discuss their implications for the future development of effective anti-cancer medicines. |
| Databáze: | OpenAIRE |
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