Prevalence and prognostic implications of psychological distress in patients with gastric cancer
| Autor: | Sung Hoon Noh, Seung Jun Kim, Kyung Ran Kim, Sun Young Rha, Su Kyung Song, Beodeul Kang, Hye Ryun Kim, Gun Min Kim, Hyun Cheol Chung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Survival Psychological distress Gastric cancer Prognosis Hospital Anxiety and Depression Scale lcsh:RC254-282 Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life Stomach Neoplasms Internal medicine Genetics medicine Odds Ratio Prevalence Humans 030212 general & internal medicine Young adult Survival analysis Aged Neoplasm Staging Aged 80 and over business.industry Cancer Odds ratio Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Distress Logistic Models Oncology 030220 oncology & carcinogenesis Physical therapy Quality of Life Population study Female business Stress Psychological Research Article |
| Zdroj: | BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017) BMC CANCER(17) BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-017-3260-2 |
| Popis: | Background The aim of this study was to investigate the prevalence and prognostic significance of psychological distress in gastric cancer patients. Methods The study population included 229 gastric cancer patients visiting Yonsei Cancer Center between November 2009 and March 2011. The distress was measured by available tools including the Modified Distress Thermometer (MDT), Hospital Anxiety and Depression Scale (HADS), and Center for Epidemiologic Studies–Depression Scale (CES-D). Patients with psychological distress were defined as those who scored above the cut-off values in both the MDT and either one of the HADS or CES-D. Results The median age of patients was 56 (range, 20 to 86) and 97 (42.4%) patients were with stage IV disease status at enrollment. The overall prevalence of psychological distress was 33.6% (95% CI: 27.5–39.8%) in 229 gastric cancer patients. In multiple logistic regression analysis, lower education level (odds ratio [OR] 2.39; 95% confidence interval [CI] 1.11–5.17, P = 0.026) and higher disease stage (OR 2.72; 95% CI 1.47–5.03, P = 0.001) were associated with psychological distress. In stage I-III disease, patients with psychological distress had worse disease-free survival (DFS) (5-year DFS rate: 60% vs 76%, P = 0.49) compared with those without psychological distress. In stage IV disease (n = 97), patients with psychological distress showed poorer overall survival than those without psychological distress (median OS (Overall Survival): 12.2 vs. 13.8 months, P = 0.019). Conclusion Psychological distress is common in patients with all stages of gastric cancer and is associated with worse outcomes. Electronic supplementary material The online version of this article (doi:10.1186/s12885-017-3260-2) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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