VEGF-D in Association With VEGFR-3 Promotes Nodal Metastasis in Human Invasive Lobular Breast Cancer
| Autor: | V. van Iterson, Päivi Heikkilä, Petri Bono, Leidenius, K. von Smitten |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Oncology
CA15-3 Cancer Research Pathology medicine.medical_specialty Endothelium VEGF receptors Vascular Endothelial Growth Factor D Breast Neoplasms Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor medicine Lymphatic vessel Humans Lymph node Neoplasm Staging 030304 developmental biology 0303 health sciences biology business.industry Nodal metastasis Endothelial Cells Cancer General Medicine Middle Aged Vascular Endothelial Growth Factor Receptor-3 medicine.disease Neoplasm Proteins 3. Good health Lymphangiogenesis Carcinoma Lobular medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis biology.protein cardiovascular system Female Lymph Nodes Lymph business |
| Zdroj: | American Journal of Clinical Pathology. 128:759-766 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | We assessed the expression of vascular endothelial growth factors (VEGF-C and VEGF-D) in breast cancer cells and the density of lymph vessels and VEGF receptor-3 (VEGFR-3)–positive vessels in and around the tumor in invasive lobular breast cancer. We found significant correlation between peritumoral lymph vessel density and presence of lymph node metastases ( P = .001) and the number of metastatic lymph nodes ( P < .001). A significant correlation was detected between tumor cell VEGF-D expression and lymph node status ( P = .001) and density of lymphatic vessel endothelial receptor (LYVE)-1–positive vessels ( P = .035). VEGFR-3+/VEGF-D+ and VEGFR-3+/VEGF-C+ tumors had a significantly higher number of metastatic lymph nodes than tumors with other staining patterns ( P < .001). Tumors positive for neither VEGF-D nor VEGFR-3 had a lower density of LYVE-1+ vessels than tumors with other staining patterns ( P = .033). Our results indicate that peritumoral lymph vessel density is associated with lymph node metastases in invasive lobular breast cancer and that invasive lobular cancer producing VEGF-D, surrounded by VEGFR-3+ vessels, has a significantly higher peritumoral lymph vessel density and a higher number of metastatic lymph nodes. |
| Databáze: | OpenAIRE |
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