Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity
Autor: | Eric H. Jensen, Todd M Tuttle, Peter W.T. Pisters, Waddah B. Al-Refaie, Beth A Virnig, Elizabeth B. Habermann |
---|---|
Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Population Soft Tissue Neoplasms Young Adult Epidemiology medicine Humans Stage (cooking) education Aged Aged 80 and over education.field_of_study business.industry Soft tissue sarcoma Hazard ratio Extremities Sarcoma Middle Aged medicine.disease Surgery Radiation therapy SSS Female Radiotherapy Adjuvant Epidemiologic Methods business |
Zdroj: | British Journal of Surgery. 97:707-713 |
ISSN: | 1365-2168 0007-1323 |
Popis: | Background Evolving evidence suggests that, in selected patients with tumour category 1 (T1) extremity soft tissue sarcoma (ESTS), surgery alone offers satisfactory results without decreasing survival. This study assessed the effect of sarcoma treatments on survival outcomes of T1 ESTS in a population-based data set. Methods Using the Surveillance, Epidemiology, and End Results database, 1618 patients with primary ESTS underwent limb-sparing surgery. Multivariable analysis was used to assess the impact of radiotherapy on overall survival (OS) and sarcoma-specific survival (SSS), adjusting for co-variables. Results Some 803 patients (49·6 per cent) underwent surgery alone for T1 ESTS. Radiotherapy in patients with low- and high-grade tumours did not result in any significant difference in OS or SSS. When stratified by grade, multivariable analysis showed that adjuvant radiotherapy was not an independent predictor of SSS (hazard ratio (HR) 1·05; P = 0·906) or OS (HR 0·89; P = 0·695) in low-grade tumours. Neither was radiotherapy a significant predictor of SSS (HR 0·87; P = 0·608) or OS (HR 0·67; P = 0·071) in high-grade tumours. Conclusion This population-based appraisal validated previous evidence supporting a role for surgery alone in the treatment of T1 ESTS. Future policies should be tailored to offer patients minimal yet effective therapy, rather than maximum tolerated therapy. |
Databáze: | OpenAIRE |
Externí odkaz: |