Loss of bacterial diversity in the sinuses is associated with lower smell discrimination scores
| Autor: | Charlotte Ballauf, Richard G. Douglas, Kristi Biswas, Julia Draf, Brett Wagner Mackenzie, Thomas Hummel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Nasal cavity Male Meatus Population Anosmia Physiology lcsh:Medicine Zoology Olfaction Biology Microbiology Article 03 medical and health sciences Olfaction Disorders 0302 clinical medicine Hyposmia Respiratory signs and symptoms RNA Ribosomal 16S Paranasal Sinuses medicine Humans Microbiome 030223 otorhinolaryngology education lcsh:Science Aged education.field_of_study Multidisciplinary Bacteria lcsh:R Middle Aged Smell 030104 developmental biology medicine.anatomical_structure Sensory Thresholds Female lcsh:Q medicine.symptom Nasal Cavity Olfactory epithelium Diversity (business) |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| ISSN: | 1438-8685 |
| DOI: | 10.1055/s-0041-1728855 |
| Popis: | Olfactory impairment affects ~ 20% of the population and has been linked to various serious disorders. Microbes in the nasal cavity play a key role in priming the physiology of the olfactory epithelium and maintaining a normal sense of smell by the host. The aim of this study was to explore the link between olfactory dysfunction and nasal bacterial communities. A total of 162 subjects were recruited for this study from a specialized olfactory dysfunction clinic and placed into one of three groups: anosmia, hyposmia or normosmia. Swabs from the nasal middle meatus were collected from each subject then processed for bacterial 16S rRNA gene sequencing. No overall differences in bacterial diversity or composition were observed between the three cohorts in this study. However, the relative abundances of Corynebacterium spp. and Streptococcus spp. were significantly (p p |
| Databáze: | OpenAIRE |
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