The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
| Autor: | Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
immunoregulation T cell Immunology Programmed Cell Death 1 Receptor T cell differentiation Receptors Antigen T-Cell Autoimmunity Review Thymus Gland Biology medicine.disease_cause Lymphocyte Activation Autoantigens B7-H1 Antigen T-Lymphocyte Subsets medicine Immunology and Allergy Homeostasis Humans Cell Lineage T cell receptor (TCR) signaling Clonal Selection Antigen-Mediated Autoimmune disease diabetes Effector T-cell receptor Models Immunological DNA Methylation medicine.disease Cell biology Histone Code medicine.anatomical_structure Diabetes Mellitus Type 1 Self Tolerance Gene Expression Regulation Cytokines lcsh:RC581-607 Immunologic Memory CD8 Signal Transduction |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2021) |
| ISSN: | 1664-3224 |
| Popis: | T cell receptor (TCR) signaling influences multiple aspects of CD4+ and CD8+ T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function. |
| Databáze: | OpenAIRE |
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