Defining the human immunodeficiency virus type 1 transmission genetic bottleneck in a region with multiple circulating subtypes and recombinant forms
| Autor: | Gama Bandawe, Andile Nofemela, Leonard Maboko, Michael Hoelscher, Zenda Woodman, Ruwayhida Thebus, Natasha T. Wood, Jinny C. Marais, Carolyn Williamson, Oliver Hoffmann |
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| Rok vydání: | 2011 |
| Předmět: |
Molecular Sequence Data
Hiv epidemic Human immunodeficiency virus (HIV) HIV Infections Genome amplification Hiv testing Biology medicine.disease_cause Tanzania Bottleneck law.invention Cohort Studies law Virology medicine Humans Transmission Genetic variability Phylogeny Recombination Genetic Transmission (medicine) HIV Population bottleneck Mbeya HIV-1 Recombinant DNA Female |
| Zdroj: | Virology. 415:107-113 |
| ISSN: | 0042-6822 |
| Popis: | The Mbeya region of Tanzania has a genetically complex HIV epidemic with multiple subtypes and recombinant forms circulating, together with a high frequency of dual infections with more than one subtype. This study aimed to determine whether this impacted the HIV-1 transmission bottleneck. A total of 210 env sequences from 22 participants were generated from recently infected women from Mbeya using the single genome amplification approach. Participants were infected with subtypes C ( n = 9), A ( n = 4), or D ( n = 1), and recombinants AC ( n = 4), CD ( n = 2), AD ( n = 1), or ACD ( n = 1). Sixteen participants (73%) were infected with a single variant; five (23%) with multiple variants; and one (4%) was dually infected. Thus the frequency of single variant infections was similar to cohorts located in genetically restricted subtype B or C epidemics, suggesting that multiple circulating subtypes and unique recombinant forms do not have a significant impact on the transmission bottleneck. |
| Databáze: | OpenAIRE |
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