Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration
| Autor: | Johann F. Coetzee, Matthew L. Stock, L. W. Wulf, L. A. Barth, R. Gehring |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cmax Administration Oral Biological Availability Cattle Diseases Pain Weaning Pharmacology chemistry.chemical_compound 4-Butyrolactone Pharmacokinetics Oral administration Animals Medicine Sulfones Dosing Horns General Veterinary business.industry Anti-Inflammatory Agents Non-Steroidal Half-life Bioavailability chemistry Area Under Curve Firocoxib Administration Intravenous Cattle Female business Half-Life |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 37:457-463 |
| ISSN: | 0140-7783 |
| DOI: | 10.1111/jvp.12124 |
| Popis: | The objective of this study was to determine the pharmacokinetics of intravenous and oral firocoxib in 10 healthy preweaned calves. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography-tandem mass spectrometry. Changes in hematology and plasma chemistry were determined using automated methods. Computer software was used to estimate pharmacokinetic parameters best described with a two-compartment model for i.v. administration and a one-compartment model for p.o. administration. Following i.v. dosing, the geometric mean (range) T1/2K10 and T1/2β were 6.7 (4.6-9.7) and 37.2 (23.5-160.4) h, respectively, Vss was 3.10 (2.10-7.22) L/kg, and CL was 121.7 (100.1-156.7) mL/h/kg. Following oral administration, geometric mean (range) Cmax was 127.9 (102.5-151.3) ng/mL, Tmax was 4.0 (2.6-5.6) h, and T1/2K10 was 18.8 (14.2-25.5) h. Bioavailability of oral firocoxib was calculated using the AUC derived from both study populations to be 98.4% (83.1-117.6%). No adverse clinical effects were evident following firocoxib administration. Pharmacokinetic analysis of i.v. and p.o. firocoxib indicates high bioavailability and a prolonged terminal half-life in preweaned calves. |
| Databáze: | OpenAIRE |
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