Mitochondrial metabolism of (D,L)-threo-9, 10-dibromo palmitic acid
| Autor: | T. L. Andreone, H. F. Mohamed, R. L. Dryer |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Male Palmitic Acids Mitochondrion Biology Biochemistry Mass Spectrometry Palmitic acid chemistry.chemical_compound Oxygen Consumption Adipose Tissue Brown Cricetinae medicine Animals Carnitine Beta oxidation Palmitoylcarnitine chemistry.chemical_classification Mesocricetus Organic Chemistry Fatty acid Cell Biology Metabolism Mitochondria Kinetics chemistry Polyunsaturated fatty acid medicine.drug |
| Zdroj: | Lipids. 15:255-262 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/bf02535836 |
| Popis: | Bromination of palmitoleic or palmitelaidic acid proceeds by trans addition and yields dibrominated products which cannot undergo beta-oxidation when incubated with mitochondria isolated from hamster brown adipose tissue. These mitochondria were selected because they have a high capacity for oxidation of C16 fatty acids and because they are readily uncoupled by an excess of free fatty acids of this chain length. The only metabolites which could be recovered from the incubation mixtures were dibromopalmitoylcarnitine and dibromopalmitoyl CoA. Free fatty acid was also recovered. Addition of synthetic carnitine or CoA esters of brominated fatty acids did not interfere with subsequent oxidation of palmitoylcarnitine. Addition of the free brominated fatty acids did not significantly increase the rate of oxidation of subsequent additions of palmitoylcarnitine, as did other known synthetic uncouplers. These results are consistent with observations by others that feeding brominated oils leads to brominated fatty acid incorporation into tissue lipids, and indicate why this is so. They also provide a possible explanation for the hepatic damage noted in feeding experiments. |
| Databáze: | OpenAIRE |
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