Plasma and urine disposition and dose proportionality of ceftiofur and metabolites in dogs after subcutaneous administration of ceftiofur sodium
| Autor: | N.L. Deleeuw, J. K. Callahan, R.L. Janose, T. F. Flook, P. J. Hamlow, T. D. Cox, S. A. Brown, A. K. Speedy, V. L. Hubbard, S.D. Folz, Thomas S. Arnold |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Injections Subcutaneous Urine Body weight chemistry.chemical_compound Dogs Dose proportionality Escherichia coli Ceftiofur sodium Animals Computer Simulation Proteus mirabilis Chromatography High Pressure Liquid Pharmacology Chromatography General Veterinary biology Dose-Response Relationship Drug biology.organism_classification Cephalosporins chemistry Plasma concentration Regression Analysis Ceftiofur Acetamide |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 18(5) |
| ISSN: | 0140-7783 |
| Popis: | Nine male dogs (10.3-13.5 kg body weight) were randomly assigned to three groups of three dogs each and administered ceftiofur sodium subcutaneously as a single dose of 0.22, 2.2, or 4.4 mg ceftiofur free acid equivalents/kg body weight. Plasma and urine samples were collected serially for 72 h and assayed for ceftiofur and metabolites (derivatized to desfuroylceftiofur acetamide) using high-performance liquid chromatography. Urine concentrations remained above the MIC90 for Escherichia coli (4.0 micrograms/mL) and Proteus mirabilis (1.0 micrograms/mL) for over 24 h after doses of 2.2 mg/kg (8.1 micrograms/mL) and 4.4 mg/kg (29.6 micrograms/mL), the interval between treatments for ceftiofur sodium in dogs, whereas urine concentrations 24 h after dosing at 0.22 mg/kg (0.1 mg/Ib) were below the MIC90 for E. coli and P. mirabilis (0.6 microgram/mL). Plasma concentrations were dose-proportional, with peak concentrations of 1.66 +/- 0.0990 micrograms/mL, 8.91 +/- 6.42 micrograms/mL, and 26.7 +/- 1.07 micrograms/mL after doses of 0.22, 2.2, and 4.4 mg/kg, respectively. The area under the plasma concentration versus time curve, when normalized to dose, was similar across all dosage groups. |
| Databáze: | OpenAIRE |
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