Synthesis, structural characterization and in vitro biological screening of some homoleptic copper(II) complexes with substituted guanidines
| Autor: | Marcel Gielen, Dick de Vos, Muhammad Rauf, Ghulam Murtaza, Erum Dilshad, Amin Badshah, Muhammad Said, Masahiro Ebihara, Bushra Mirza |
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| Rok vydání: | 2012 |
| Předmět: |
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Molecular Antifungal Agents Magnetic Resonance Spectroscopy Cell Survival Stereochemistry chemistry.chemical_element Antineoplastic Agents Microbial Sensitivity Tests Crystal structure Guanidines Inhibitory Concentration 50 chemistry.chemical_compound X-Ray Diffraction Cell Line Tumor Spectroscopy Fourier Transform Infrared Drug Discovery Organometallic Compounds Animals Humans Homoleptic Guanidine Pharmacology Organic Chemistry General Medicine Nuclear magnetic resonance spectroscopy Carbon-13 NMR Copper Anti-Bacterial Agents chemistry X-ray crystallography Spectrophotometry Ultraviolet Artemia Single crystal |
| Zdroj: | European Journal of Medicinal Chemistry. 48:26-35 |
| ISSN: | 0223-5234 |
| Popis: | A series of homoleptic copper(II) complexes (1a-8a) with N,N',N″-trisubstituted guanidines, [Cu(II){PhCONHC(NHR)NPh}(2)] (where R = phenyl (1a), n-butyl (2a), sec-butyl (3a), cyclohexyl (4a), 1-naphthyl (5a), 2,4-dichlorophenyl (6a), 3,4-dichlorophenyl (7a), and 3,5-dichlorophenyl (8a)) have been synthesized and characterized by elemental analyses, FT-IR, UV-visible, (1)H and (13)C NMR spectroscopy, and single crystal X-ray diffraction analysis. The X-ray crystal structures revealed that the complexes 2a and 4a are mononuclear in the solid state and that the geometry around the copper atom is nearly square planar. In both the cases, N,N',N″-trisubstituted guanidine ligands have been coordinated to the Cu(II) through the oxygen and nitrogen atoms. The synthesized guanidines and their complexes were initially screened for their anti-microbial activities, and Brine Shrimps Lethality assay. The complexes were also screened for in vitro cytotoxicity activity in human cell lines carcinomas A498, EVSAT, H226, IGROV, M19, MCF-7 and WIDR. The results show a moderate level of cytotoxicity against these seven human cancer cell lines as compared with standard chemotherapeutic drugs. |
| Databáze: | OpenAIRE |
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