Distinct T‐cell subtypes induced with whole cell and acellular pertussis vaccines in children
| Autor: | G. Murphy, F. Shackley, Leif Gothefors, Kingston H. G. Mills, K. Øymar, M. Ryan, J. Storsaeter, Lennart Nilsson, Elizbeth Miller, Elizabeth J. Ryan |
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| Rok vydání: | 1998 |
| Předmět: |
Bordetella pertussis
T cell Immunology Cell Culture Techniques Immunization Secondary chemical and pharmacologic phenomena Lymphocyte Activation Immunophenotyping Interferon-gamma Immune system Antigen T-Lymphocyte Subsets medicine Humans Immunology and Allergy Child Whooping cough Pertussis Vaccine Antigens Bacterial Immunity Cellular Innate immune system biology business.industry Vaccination biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Virology medicine.anatomical_structure Immunization bacteria Interleukin-5 business Research Article |
| Zdroj: | Immunology. 93:1-10 |
| ISSN: | 1365-2567 0019-2805 |
| DOI: | 10.1046/j.1365-2567.1998.00401.x |
| Popis: | Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection induced by vaccination remains to be defined. We have examined cellular immune responses in children immunized with a range of acellular and whole cell pertussis vaccines. Immunization of children with a potent whole-cell vaccine induced B. pertussis-specific T cells that secreted interferon-gamma (IFN-gamma), but not interleukin-5 (IL-5). In contrast, T cells from children immunized with acellular pertussis vaccines secreted IFN-gamma and/or IL-5 following stimulation with B. pertussis antigens in vitro. These observations suggest that protective immunity conferred by whole-cell vaccines, like natural immunity, is mediated by type 1 T cells, whereas the mechanism of immune protection generated with acellular vaccines may be more heterogeneous, involving T cells that secreted type 1 and type 2 cytokines. |
| Databáze: | OpenAIRE |
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