An animal model to study ACL reconstruction during growth
| Autor: | J. Brand, Karsten Knobloch, Rupert Meller, Christian Krettek, Eric Hesse, Carl Haasper, Stefan Hankemeier, Jörn Westhoff, Michael Jagodzinski |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Research groups Future studies Anterior cruciate ligament Biomedical Engineering Biophysics Health Informatics Bioengineering Bone and Bones Biomaterials Animal model Equivalent model Contralateral knee Animals Medicine Orthopedic Procedures Anterior Cruciate Ligament Orthodontics Bone Development Sheep business.industry Plastic Surgery Procedures musculoskeletal system Human situation Surgery medicine.anatomical_structure Models Animal Joints business Information Systems Large animal |
| Zdroj: | Technology and Health Care. 17:403-410 |
| ISSN: | 1878-7401 0928-7329 |
| Popis: | Controversy exists in the literature regarding the most appropriate treatment for anterior cruciate ligament (ACL) ruptures in the skeletally immature patient. To study the histological and biomechanical stages following ACL reconstruction during growth, it is necessary to establish an equivalent model to replicate the situation of an immature skeleton. In the present study we evaluated a large animal model of ACL reconstruction during growth using skeletally immature sheep. In contrast to existing models we did not intend to provoke growth disturbances. Instead, we identified those criteria known to be essential to prevent growth disturbances in the human situation and transformed them into an animal model. Applying those criteria to skeletally immature sheep at an age of four months, we performed a fully transphyseal ACL reconstruction of their right knee. The contralateral knee served as a control. The sheep were then sacrificed 3, 6, 12 and 24 weeks after surgery. This animal model is described in detail in the present manuscript. Basic science data are presented in order to 1) make it easier for other research groups to study ACL reconstruction during growth using our model and 2) to improve this model by modifying the one or other detail of the proposed technique. Using this model, remaining open questions concerning ACL reconstruction during growth can be addressed in future studies. |
| Databáze: | OpenAIRE |
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