Formulation and Evaluation of Novel Thiolated Intra Pocket Periodontal Composite Membrane of Doxycycline
| Autor: | Ali Iqbal, Sohail Akhtar, Sobia Razzaq, Gul Shahnaz, Hina Naz, Rabia Arshad, Nasir M. Ahmad, Asma Kanwal |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Drug Compounding Kinetics Drug Evaluation Preclinical Pharmaceutical Science 02 engineering and technology Aquatic Science 030226 pharmacology & pharmacy Chitosan 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Drug Delivery Systems Drug Discovery Mucoadhesion Animals Humans Periodontal Pocket Sulfhydryl Compounds Ecology Evolution Behavior and Systematics chemistry.chemical_classification Ecology Goats Swelling capacity General Medicine 021001 nanoscience & nanotechnology In vitro Anti-Bacterial Agents Solvent Membrane chemistry Doxycycline Thiol Biophysics 0210 nano-technology Agronomy and Crop Science |
| Zdroj: | AAPS PharmSciTech. 20(8) |
| ISSN: | 1530-9932 |
| Popis: | Localized intra-pocket, retentive, biodegradable, prolonged release thiolated membrane can provide an improved therapeutic efficacy of doxycycline at the site of action with evading off target side effects. To this end, thiolated chitosan-hyaluronic acid composite polymeric complex next-generation of the periodontal membrane was manufactured by solvent casting method. FTIR spectroscopic analysis displayed successful immobilization of thiol groups on the manufactured thiolated periodontal membrane. Moreover, XRD, DSC, AFM and TGA of the membrane confirmed the compatibility of ingredients and modifications in surface chemistry. The thiolated periodontal film was also investigated in terms of thickness, weight uniformity, water-uptake capacity, drug content, pH, entrapment efficiency, lysozymal degradation and release patterns. Also, mucoadhesion profile was explored on gingival mucosa. The immobilized thiol groups on thiolated chitosan and thiolated hyaluronate were found to be 168 ± 11 μM/g (mean ± SD, n = 3) and 189 ± 8 μM/g (mean ± SD, n = 3) respectively. Swelling capacity of the thiolated periodontal membrane was significantly ∼2-fold higher (p |
| Databáze: | OpenAIRE |
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