Extreme diversification driven by parallel events of massive loss of heterozygosity in the hybrid lineage of Candida albicans
| Autor: | Ester Saus, Teun Boekhout, Toni Gabaldón, Verónica Mixão |
|---|---|
| Přispěvatelé: | Barcelona Supercomputing Center, Mitchell, A, Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Yeast Research, Evolutionary and Population Biology (IBED, FNWI) |
| Rok vydání: | 2020 |
| Předmět: |
AcademicSubjects/SCI01140
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC] Candida albicans/genetics AcademicSubjects/SCI00010 Lineage (evolution) Loss of Heterozygosity comparative genomics yeast AcademicSubjects/SCI01180 Genome Loss of heterozygosity 03 medical and health sciences Genetic Fungal genetics Candida albicans Genetics Fungal Genetics Clade Hybridization 030304 developmental biology Comparative genomics 0303 health sciences Candida stellatoidea biology Strain (biology) 030302 biochemistry & molecular biology Genomics biology.organism_classification Yeast Corpus albicans Genòmica Fungal Genetics and Genomics AcademicSubjects/SCI00960 Hybridization Genetic |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Genetics Genetics, 217(2). Genetics Society of America Genetics, 217(2):iyaa004. Genetics Society of America |
| ISSN: | 1943-2631 0016-6731 |
| DOI: | 10.1093/genetics/iyaa004 |
| Popis: | Candida albicans is the most commonly reported species causing candidiasis. The taxonomic classification of C. albicans and related lineages is controversial, with Candida africana (syn. C. albicans var. africana) and Candida stellatoidea (syn. C. albicans var. stellatoidea) being considered different species or C. albicans varieties depending on the authors. Moreover, recent genomic analyses have suggested a shared hybrid origin of C. albicans and C. africana, but the potential parental lineages remain unidentified. Although the genomes of C. albicans and C. africana have been extensively studied, the genome of C. stellatoidea has not been sequenced so far. In order to get a better understanding of the evolution of the C. albicans clade, and to assess whether C. stellatoidea could represent one of the unknown C. albicans parental lineages, we sequenced C. stellatoidea type strain (CBS 1905). This genome was compared to that of C. albicans and of the closely related lineage C. africana. Our results show that, similarly to C. africana, C. stellatoidea descends from the same hybrid ancestor as other C. albicans strains and that it has undergone a parallel massive loss of heterozygosity. This work was funded by the European Union’s Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant Agreement No. H2020-MSCA-ITN-2014-642095. T.G. group also acknowledges support from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for grant PGC2018-099921-B-I00 co-founded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857; and grants from the European Union’s Horizon 2020 Research and Innovation Program under the grant agreements ERC-2016-724173 and MSCA-747607. T.G. also receives support from an INB Grant (PT17/0009/0023—ISCIII-SGEFI/ERDF). |
| Databáze: | OpenAIRE |
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