Pharmacodynamics of mivacurium in infants
| Autor: | O A, Meretoja, T, Taivainen, K, Wirtavuori, K T, Olkkola |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Neuromuscular Junction
Electromyography Anesthesia General Drug Administration Schedule Bolus (medicine) Infusion Procedure Medicine Potency Humans Alfentanil Infusion Pumps medicine.diagnostic_test Dose-Response Relationship Drug business.industry Computers Infant Nerve Block Isoquinolines Adductor pollicis muscle Mivacurium Anesthesiology and Pain Medicine Elective Surgical Procedures Anesthesia Pharmacodynamics business Closed loop medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | British journal of anaesthesia. 73(4) |
| ISSN: | 0007-0912 |
| Popis: | A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular block in 15 infants less than 1 yr of age. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50-100 micrograms kg-1 h-1. Neuromuscular block was produced by repeated bolus doses of mivacurium 0.1 mg kg-1; subsequently the target neuromuscular block was maintained by a closed loop infusion. Dose potency of mivacurium was similar to that previously published in children with a similar anaesthetic technique. Mean mivacurium requirement for 95% neuromuscular block was 820 (SD 300) micrograms kg-1 h-1, which represented an hourly requirement of 6.6 (1.5) individual ED95 doses. Infusion requirement for 50% neuromuscular block was 320 (150) micrograms kg-1 h-1. These infusion rates were similar to those in children. No side effects of mivacurium were noticed. |
| Databáze: | OpenAIRE |
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