The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking
| Autor: | Ute Nöthlings, Kolade Oluwagbemigun, Julia Langenau, Manuela M. Bergmann, Heiner Boeing |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Alcohol Drinking Metabolite Alcohol lcsh:TX341-641 Article smoking 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Negatively associated acylcarnitines Environmental health Germany targeted metabolomics Medicine Humans 030212 general & internal medicine Prospective Studies Adverse effect Aged amino acids Nutrition and Dietetics Smokers business.industry alcohol Confounding Middle Aged metabolite patterns European Prospective Investigation into Cancer and Nutrition 030104 developmental biology chemistry Smoking status Blood Alcohol Content Female business Energy Metabolism lipid metabolites Alcohol consumption lcsh:Nutrition. Foods and food supply Biomarkers Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 10, p 2331 (2019) Nutrients Volume 11 Issue 10 |
| ISSN: | 2072-6643 |
| Popis: | Alcohol consumption is an important lifestyle factor that is associated with several health conditions and a behavioral link with smoking is well established. Metabolic alterations after alcohol consumption have yet to be comprehensively investigated. We studied the association of alcohol consumption with metabolite patterns (MPs) among 2433 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, and a potential modification by smoking. Alcohol consumption was self-reported through dietary questionnaires and serum metabolites were measured by a targeted approach. The metabolites were summarized as MPs using the treelet transform analysis (TT). We fitted linear models with alcohol consumption continuously and in five categories. We stratified the continuously modelled alcohol consumption by smoking status. All models were adjusted for potential confounders. Among men, alcohol consumption was positively associated with six MPs and negatively associated with one MP. In women, alcohol consumption was inversely associated with one MP. Heavy consumers differed from other consumers with respect to the &ldquo Long and short chain acylcarnitines&rdquo MP. Our findings suggest that long and short chain acylcarnitines might play an important role in the adverse effects of heavy alcohol consumption on chronic diseases. The relations seem to depend on gender and smoking status. |
| Databáze: | OpenAIRE |
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