c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcRγ-chain
| Autor: | Gosse J. Adema, Jan G. J. van de Winkel, Jantine E. Bakema, Paul J. Coffer, Jeanette H. W. Leusen, Marjolein van Egmond, Yvonne Kok, Simone de Haij, J. M. Bakker, Ida H. Hiemstra |
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| Přispěvatelé: | Molecular cell biology and Immunology, Surgery, CCA - Immuno-pathogenesis |
| Rok vydání: | 2010 |
| Předmět: |
Transcriptional Activation
Lysis Phagocytosis Amino Acid Motifs Immunology Receptors Fc Biology Protein expression Mice Antigens CD Immune Regulation [NCMLS 2] Animals Humans Immunology and Allergy Protein Interaction Domains and Motifs Transgenes RNA Small Interfering Receptor COP9 Signalosome Complex Protein Stability Binding protein Receptors IgG c-jun Intracellular Signaling Peptides and Proteins U937 Cells Molecular biology Cell biology Signalling NIH 3T3 Cells Ectopic expression Peptide Hydrolases Protein Binding |
| Zdroj: | European Journal of Immunology, 40(7), 2035-2040. Wiley-VCH Verlag European Journal of Immunology, 40, 7, pp. 2035-40 Bakema, J E, Hiemstra, I H, Bakker, J, de Haij, S, Kok, Y, Adema, G, van Egmond, M, Coffer, PJ, Winkel, J G J & Leusen, J H W 2010, ' c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of Fc alpha RI and FcR gamma-chain ', European Journal of Immunology, vol. 40, no. 7, pp. 2035-2040 . https://doi.org/10.1002/eji.200939985 European Journal of Immunology, 40, 2035-40 |
| ISSN: | 0014-2980 |
| Popis: | Contains fulltext : 87311.pdf (Publisher’s version ) (Closed access) The receptor for IgA, FcalphaRI or CD89, is expressed on myeloid cells and can trigger phagocytosis, tumor cell lysis, and release of inflammatory mediators. These functions critically depend on the associated FcR gamma-chain; however, some biological functions, like receptor internalization, are solely mediated by FcalphaRI alpha-chain. Little is known as to how FcalphaRI regulates these processes and the FcalphaRI intracellular domain does not contain recognized signalling motifs. We searched for associating proteins and identified c-Jun activating binding protein 1 (JAB1) as a binding partner specifically for FcalphaRI. We found increased FcalphaRI surface expression after ectopic expression of JAB1 as well as diminished protein levels of total FcR gamma-chain levels after JAB1 knock-down. These data functionally link JAB1 with controlling protein expression levels of FcalphaRI-FcR gamma-chain protein complex. 01 juli 2010 |
| Databáze: | OpenAIRE |
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