Synchrony and entrainment properties of robust circadian oscillators
| Autor: | Neda Bagheri, Francis J. Doyle, Linda R. Petzold, Kirsten Meeker, Stephanie R. Taylor |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Biological clock
Models Neurological Circadian clock Population Biomedical Engineering Biophysics Bioengineering Biology Models Biological Biochemistry Biomaterials Control theory Animals Circadian rhythm education Neurons Stochastic Processes education.field_of_study Control objective Stochastic process Circadian Rhythm Drosophila melanogaster Entrainment (chronobiology) Biological network Signal Transduction Research Article Biotechnology |
| Zdroj: | Journal of The Royal Society Interface. 5 |
| ISSN: | 1742-5662 1742-5689 |
| DOI: | 10.1098/rsif.2008.0045.focus |
| Popis: | Systems theoretic tools (i.e. mathematical modelling, control, and feedback design) advance the understanding of robust performance in complex biological networks. We highlight phase entrainment as a key performance measure used to investigate dynamics of a single deterministic circadian oscillator for the purpose of generating insight into the behaviour of a population of (synchronized) oscillators. More specifically, the analysis of phase characteristics may facilitate the identification of appropriate coupling mechanisms for the ensemble of noisy (stochastic) circadian clocks. Phase also serves as a critical control objective to correct mismatch between the biological clock and its environment. Thus, we introduce methods of investigating synchrony and entrainment in both stochastic and deterministic frameworks, and as a property of a single oscillator or population of coupled oscillators. |
| Databáze: | OpenAIRE |
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