| Přispěvatelé: |
Falcone, Marco, Suardi, Lorenzo Roberto, Tiseo, Giusy, Galfo, Valentina, Occhineri, Sara, Verdenelli, Stefano, Ceccarelli, Giancarlo, Poli, Melita, Merli, Marco, Bavaro, Davide, Carretta, Anna, Nunnari, Giuseppe, Venanzi Rullo, Emmanuele, Trecarichi, Enrico Maria, Papalini, Chiara, Franco, Antonina, Del Vecchio, Rosa Fontana, Bianco, Vincenzo, Punzi, Rodolfo, Francisci, Daniela, Rubino, Raffaella, Torti, Carlo, Puoti, Massimo, Carbonara, Sergio, Cascio, Antonio, Saracino, Annalisa, Santantonio, Teresa, Venditti, Mario, Menichetti, Francesco |
| Popis: |
Objectives To describe clinical characteristics and outcomes of COVID-19 patients who developed secondary infections due to carbapenem-resistant Enterobacterales (CRE). Methods Retrospective observational study including COVID-19 patients admitted to 12 Italian hospitals from March to December 2020 who developed a superinfection by CRE. Superinfection was defined as the occurrence of documented bacterial infection >48 h from admission. Patients with polymicrobial infections were excluded. Demographic, clinical characteristics and outcome were collected. Isolates were classified as KPC, metallo-β-lactamase (MBL) and OXA-48-producing CRE. A Cox regression analysis was performed to identify factors independently associated with 30 day mortality. Results Overall, 123 patients (median age 66 years, IQR 59–75) were included. The majority of infections occurred in the ICU (81, 65.9%), while 42 (34.1%) in medical wards. The most common types of infection were bloodstream infections (BSI) (n = 64, 52%), followed by urinary-tract infections (UTI) (n = 28, 22.8%), hospital-acquired/ventilator-associated pneumonia (HAP/VAP) (n = 28, 22.8%), intra-abdominal infections (n = 2, 1.6%) and skin infections (n = 1, 0.8%). Sixty-three (51.2%) infections were caused by KPC-, 54 (43.9%) by MBL-, and 6 (4.8%) by OXA-48-producing CRE. Thirty-day mortality was 33.3% (41/123). On Cox regression analysis, HAP/VAP compared with UTI (HR 7.23, 95% CI 2.09–24.97, P = 0.004), BSI compared with UTI (HR 3.96, 95% CI, 1.33–11.77, P = 0.004), lymphopenia on admission (HR 3, 95% CI 1.44–6.26, P = 0.003) and age (HR 1.05, 95% CI 1.02–1.08, P = 0.002) were predictors of 30 day mortality. Conclusions Superinfections by CRE were associated with high risk of 30 day mortality in patients with COVID-19. HAP/VAP was the strongest predictor of death in these patients. |
