The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer
| Autor: | Guopei Zhu, Hong Mei Ying, Shao Qin He, Xiao Peng Xiong, Chaosu Hu, J.J. Lu, Xin Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Time Factors medicine.medical_treatment lcsh:R895-920 lcsh:RC254-282 Radiosurgery Carcinoma Lewis Lung Mice In vivo medicine Animals Radiology Nuclear Medicine and imaging Lung cancer Radiation Injuries Survival analysis Cell Proliferation business.industry Research Dose fractionation Tumor control medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Single fraction Tumor Burden Radiation therapy Mice Inbred C57BL Oncology Radiology Nuclear Medicine and imaging Female Dose Fractionation Radiation Radiotherapy Conformal business Nuclear medicine Neoplasm Transplantation |
| Zdroj: | Radiation Oncology, Vol 6, Iss 1, p 4 (2011) Radiation Oncology (London, England) Wang, Xin; Xiong, Xiao-Peng; Lu, Jiade; Zhu, Guo-Pei; He, Shao-Qin; Hu, Chao-Su; et al.(2011). The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer. Radiation Oncology, 6(1), 4. doi: http://dx.doi.org/10.1186/1748-717X-6-4. Retrieved from: http://www.escholarship.org/uc/item/97w894hn |
| Popis: | Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups: the normal control group, the single fraction with 18 Gy group, the two subfractions with 30 min interval group, the seven subfractions with 5 min interval group, the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency, the tumor growth delay and the mice survival time were analyzed. Results The tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy (P < 0.05). The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P < 0.05). There was no significant difference between groups with same delivery time (P > 0.05). Compared to the group with single fraction of 18 Gy, the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min. Conclusions The prolonged delivery time with same radiation dose shorten the tumor growth delay and survival time in the mice implanted with Lewis lung cancer. The anti-tumor effect decreased with elongation of the total interfractional time. |
| Databáze: | OpenAIRE |
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