| Autor: |
Mark J. Jameson, Daniel Gioeli, Emanuel F. Petricoin, Julie Wulfkuhle, Linnea E. Taniguchi, Abel P. David, Rolando E. Mendez, Adam Spencer, Christine E. Lehman, Michael I. Dougherty |
| Rok vydání: |
2023 |
| Popis: |
Supplemental Table 2: The signaling impact of IGF1R activation in sensitive vs. resistant cell lines for all analytes examined by RPPA. RPPA was performed as described in the Methods. For each protein in each cell line, an IGF impact ratio was calculated by dividing the protein level in cells treated with EGFR-TKI plus desIGF1 by the protein level in cells treated with EGFR-TKI alone. For each protein and EGFR-TKI, the average IGF1 impact ratio across all sensitive cell lines was divided by the same average ratio for all resistant cell lines; this ratio represents the relative change in protein level in sensitive vs. resistant cells for a given EGFR-TKI and was rank-ordered to identify the proteins most likely associated with IGF1R-based treatment resistance. Amino acid residues indicate sites of phosphorylation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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