HIV type 1 coreceptor tropism, CCR5 genotype, and integrase inhibitor resistance profiles in Vietnam: implications for the introduction of new antiretroviral regimens
| Autor: | Michael J. Carr, William W. Hall, Jonathan L.E. Dean, Linda Dunford, Trinh Thi Diem Do, Quynh Phuong Luu, Suzie Coughlan, Jeff Connell, Hien M. Nguyen, Lan Anh Nguyen Thi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Genotype Receptors CCR5 viruses Immunology Molecular Sequence Data Human immunodeficiency virus (HIV) Integrase inhibitor HIV Infections Drug resistance Genome Viral Biology HIV Envelope Protein gp120 medicine.disease_cause Tropism Virus Virology Raltegravir Potassium Drug Resistance Viral medicine Humans Genetic Predisposition to Disease HIV Integrase Inhibitors Genetics Infectivity virus diseases Pyrrolidinones Infectious Diseases Vietnam Cohort CCR5 Receptor Antagonists Coreceptor tropism HIV-1 Female |
| Zdroj: | AIDS research and human retroviruses. 28(10) |
| ISSN: | 1931-8405 |
| Popis: | In Vietnam, where an estimated 280,000 people will be HIV-positive by 2012, recommended antiretroviral regimens do not include more recently developed therapeutics, such as Integrase inhibitors (INI) and coreceptor antagonists. This study examined HIV-1 coreceptor tropism and INI drug resistance profiles, in parallel with CCR5 genotypes, in a cohort of 60 HIV-positive individuals from different regions of Vietnam. No evidence of INI resistance was detected. Some 40% of individuals had X4-tropic HIV-1, making them unsuitable for treatment with CCR5 antagonists. We identified a novel CCR5 variant-S272P-along with other, previously reported variants: G106R, C178R, W153C, R223Q, and S336I. Interestingly, CCR5 variants known to affect HIV-1 infectivity were observed only in individuals harboring X4-tropic virus. Together, this study presents valuable baseline information on HIV-1 INI resistance, coreceptor tropism, and CCR5 variants in HIV-positive individuals in Vietnam. This should help inform policy on the future use of novel antiretrovirals in Vietnam. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|