P- and E-selectin-deficient mice are susceptible to cerebral ischemia–reperfusion injury
| Autor: | Paul S. Frenette, Denisa D. Wagner, Yanming F. Wang, Sulpicio G. Soriano |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
P-selectin Ratón Ischemia Mice Transgenic Central nervous system disease Mice Necrosis Internal medicine E-selectin medicine Animals Genetic Predisposition to Disease cardiovascular diseases Molecular Biology biology Vascular disease business.industry General Neuroscience Cerebral Infarction medicine.disease P-Selectin Endocrinology Ischemic Attack Transient Reperfusion Injury Immunology biology.protein Neurology (clinical) E-Selectin Genetic Engineering business Reperfusion injury Selectin Developmental Biology |
| Zdroj: | Brain Research. 835:360-364 |
| ISSN: | 0006-8993 |
| Popis: | We examined brain sections from P- and E-selectin-deficient mice (−/−) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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