Limb-Threatening Acute Venous Thromboembolism in a Patient Undergoing Postarrest Therapeutic Hypothermia
| Autor: | Michael C. Kurz, Jenna M. Holzhausen, Amanda R. Stahl, Kelly N. Sawyer, Larissa Dub |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Fatal outcome medicine.medical_treatment Treatment outcome Critical Care and Intensive Care Medicine Hypothermia induced Fatal Outcome Hypothermia Induced Angioplasty medicine Humans cardiovascular diseases Intensive care medicine Blood Coagulation Aged Thrombectomy business.industry Anticoagulants Venous Thromboembolism Heparin Hypothermia equipment and supplies Heart Arrest Treatment Outcome Anesthesiology and Pain Medicine Acute Disease Female Liver dysfunction medicine.symptom business Venous thromboembolism medicine.drug |
| Zdroj: | Therapeutic Hypothermia and Temperature Management. 5:228-234 |
| ISSN: | 2153-7933 2153-7658 |
| DOI: | 10.1089/ther.2015.0019 |
| Popis: | Postcardiac arrest patients are at high risk for developing venous thromboembolism (VTE). Current postarrest guidelines do not provide recommendations for prevention or surveillance of VTE and there is little guidance regarding the optimal prophylaxis or treatment of VTE during therapeutic hypothermia (TH). Many patients develop acute liver dysfunction resulting from severe global hypoperfusion during cardiac arrest, compounding concerns for bleeding with the initiation of TH. However, significant VTE may occur following arrest and can contribute to additional morbidity and mortality. The pharmacokinetics of anticoagulation, the routine treatment for VTE, have not been extensively researched or tested under hypothermic conditions. Standard approaches for prevention and treatment have been utilized, such as unfractionated heparin, but their efficacy remains uncertain. This case illustrates the significant imbalance of coagulation in a postcardiac arrest patient undergoing TH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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