Soluble Camptothecin Derivatives Prepared by Click Cycloaddition Chemistry on Functional Aliphatic Polyesters
| Autor: | Todd Emrick, Bryan Parrish |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Azides Molecular Structure Ethylene oxide Chemistry Polyesters Organic Chemistry Biomedical Engineering Pharmaceutical Science Alkyne Bioengineering Polymer Cycloaddition Polyester chemistry.chemical_compound Solubility Chromatography Gel PEGylation Copolymer Organic chemistry Camptothecin Hydrophobic and Hydrophilic Interactions Biotechnology Conjugate |
| Zdroj: | Bioconjugate Chemistry. 18:263-267 |
| ISSN: | 1520-4812 1043-1802 |
| DOI: | 10.1021/bc060201d |
| Popis: | Aliphatic polyesters are of interest as biomaterials and drug-delivery vehicles, as their ability to degrade under physiological conditions provides a mechanism for both drug release and clearance of the polymer from the body. Presented here is the synthesis of a polyester-drug graft copolymer conjugate, enabled by click cycloaddition of azide-functionalized camptothecin derivatives with alkyne-functionalized aliphatic polyesters. Further grafting of residual alkyne groups with azide-terminated poly(ethylene oxide) gave a water-soluble polyester-camptothecin conjugate. Control over PEGylation and drug loading, inherent to the graft copolymer design, opens versatile routes to new materials with potential utility in polymer therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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