Complex pharmacology of natural cannabivoids: Evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
| Autor: | Assunta Imperato, Bernadette Jeantaud, Marie-Christine Dubroeucq, François Petitet, Michel Reibaud |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Agonist Cannabinoid receptor medicine.drug_class Receptors Drug Pharmacology Binding Competitive Partial agonist General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Cerebellar Cortex chemistry.chemical_compound Piperidines mental disorders medicine Cannabinoid receptor type 2 Animals Cannabidiol Dronabinol General Pharmacology Toxicology and Pharmaceutics Receptors Cannabinoid Analgesics Chemistry organic chemicals Cell Membrane Brain Cannabinoid Receptor Agonists General Medicine Cyclohexanols Rats Cannabinol Pyrazoles GPR18 Guanosine Triphosphate Rimonabant medicine.drug |
| Zdroj: | Life Sciences. 63:PL1-PL6 |
| ISSN: | 0024-3205 |
| Popis: | Delta9-tetrahydrocannabinol (delta9-THC), cannabinol and cannabidiol are three important natural cannabinoids from the Marijuana plant (Cannabis sativa). Using [35S]GTP-gamma-S binding on rat cerebellar homogenate as an index of cannabinoid receptor activation we show that: delta9-THC does not induce the maximal effect obtained by classical cannabinoid receptor agonists such as CP55940. Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range. |
| Databáze: | OpenAIRE |
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