Reappraisal of amoxycillin absorption kinetics
| Autor: | Claude Carbon, A. Deslandes, J. M. Brogard, J F Westphal |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.drug_class Antibiotics Kinetics Administration Oral Biological Availability Absorption (skin) Pharmacology Intestinal absorption chemistry.chemical_compound Pharmacokinetics medicine Humans Pharmacology (medical) Drug Carriers Dipeptide Amoxicillin Small intestine Infectious Diseases medicine.anatomical_structure Intestinal Absorption Biochemistry chemistry Injections Intravenous Regression Analysis medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 27:647-654 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/27.5.647 |
| Popis: | Interest in the intestinal absorption mechanisms of drugs has increased because transepithelial passage across the gut does not necessarily follow a passive diffusion process. Amoxycillin, like other amino-beta-lactam antibiotics, has been demonstrated in vitro to use the dipeptide carrier-mediated system in rodent small intestine. In order to assess the in-vivo relevance of these data, we applied the Loo-Riegelman method for a reappraisal of amoxycillin absorption kinetics in healthy human volunteers. The results showed evidence of a saturable carrier-mediated uptake of this antibiotic. With respect to the in-vitro data previously published, the dipeptide carrier system would appear to be the most likely transport mechanism. |
| Databáze: | OpenAIRE |
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