Development of ocular drug delivery systems using molecularly imprinted soft contact lenses
| Autor: | Faezeh Tashakori-Sabzevar, Seyed Ahmad Mohajeri |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Drug
Eye Diseases genetic structures Polymers media_common.quotation_subject Pharmaceutical Science Administration Ophthalmic Nanotechnology Eye Molecular Imprinting Drug Delivery Systems Drug Discovery Animals Humans Medicine media_common Pharmacology business.industry Organic Chemistry Molecularly imprinted polymer Hydrogels Contact Lenses Hydrophilic Controlled release eye diseases Ophthalmic solutions Targeted drug delivery Drug Design Drug delivery sense organs Ophthalmic Solutions business |
| Zdroj: | Drug Development and Industrial Pharmacy. 41:703-713 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639045.2014.948451 |
| Popis: | Recently, significant advances have been made in order to optimize drug delivery to ocular tissues. The main problems in ocular drug delivery are poor bioavailability and uncontrollable drug delivery of conventional ophthalmic preparations (e.g. eye drops). Hydrogels have been investigated since 1965 as new ocular drug delivery systems. Increase of hydrogel loading capacity, optimization of drug residence time on the ocular surface and biocompatibility with the eye tissue has been the main focus of previous studies. Molecular imprinting technology provided the opportunity to fulfill the above-mentioned objectives. Molecularly imprinted soft contact lenses (SCLs) have high potentials as novel drug delivery systems for the treatment of eye disorders. This technique is used for the preparation of polymers with specific binding sites for a template molecule. Previous studies indicated that molecular imprinting technology could be successfully applied for the preparation of SCLs as ocular drug delivery systems. Previous research, particularly in vivo studies, demonstrated that molecular imprinting is a versatile and effective method in optimizing the drug release behavior and enhancing the loading capacity of SCLs as new ocular drug delivery systems. This review highlights various potentials of molecularly imprinted contact lenses in enhancing the drug-loading capacity and controlling the drug release, compared to other ocular drug delivery systems. We have also studied the effects of contributing factors such as the type of comonomer, template/functional monomer molar ratio, crosslinker concentration in drug-loading capacity, and the release properties of molecularly imprinted hydrogels. |
| Databáze: | OpenAIRE |
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