Pretreatment with an Aerosol Foam Containing Calcipotriene and Betamethasone Strongly Improves the Efficacy of Narrow-Band UVB Phototherapy

Autor: Gaetano Licata, Mariachiara Arisi, Marina Venturini, Mariateresa Rossi, Cesare Tomasi, Irene Calzavara-Pinton, Piergiacomo Calzavara-Pinton
Rok vydání: 2022
Předmět:
Zdroj: Dermatology and Therapy. 12:2161-2171
ISSN: 2190-9172
2193-8210
Popis: Narrow-band (NB) UVB has been combined with a number of topical treatments. However, there have been no specific data regarding treatment results of a fixed combination of calcipotriene 50 μg/g plus betamethasone 0.5 mg/g aerosol foam (Cal/BD) combined with NB-UVB phototherapy so far.To assess the efficacy of Cal/BD foam coupled to twice-weekly NB-UVB and whether this combined regimen requires fewer UVB treatments and a lower cumulative UVB dose compared to phototherapy alone.This cross-sectional, prospective, parallel-group study enrolled 187 consecutive moderate-to-severe psoriatic patients who were allocated to two groups in a 1:2 ratio. The overall duration of the treatment cycle was 12 weeks. At baseline and after 2, 4, 8 and 12 weeks, we registered the modified (not considering head lesions) PASI, the number of Cal/BD applications, the NRS score for itching and the adverse effects.The combined regimen was more effective in clearing psoriasis [final mPASI: 2.1 (0; 8.2) versus 4.4 (0; 19.6); p 0.01] and reducing itching [(final NRS score for itching: 0 (0; 3) versus 1 (0; 4); p 0.01]. Fewer exposures [12 (4; 20) versus 24 (8; 24); p 0.01] and a lower cumulative UVB dose [6.1 (5.4; 9.3) J cmCal/BD + NB-UVB is a very effective treatment that produces a rapid improvement in clinical lesions and itching and can be considered a valuable alternative to systemic treatments for psoriasis.
Databáze: OpenAIRE
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