Supplementary Figure 7 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
| Autor: | Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen |
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| Rok vydání: | 2023 |
| Popis: | PDF file - 123KB, Effect of MLN4924 on Bim expression in CLL. CLL cells were co-cultured with CD40L-expressing stroma for 24 hours, followed by incubation with 1 microM MLN4924 or vehicle control. Cell were lysed at 24 hours and subjected to immunoblotting. Raji cells (American Type Culture Collection) were cultured in RPMI 1640 with 10% FBS without (first lane) or with (second lane) 50 microg/L phorbol 12-myristate 13-acetate for 30 min to serve as control for expression of phospho-Bim. |
| Databáze: | OpenAIRE |
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