Allophylus serratus: a plant with potential anti-ulcerogenic activity
| Autor: | Vinay Singh Chauhan, Poonam Dharmani, Gautam Palit, Pushpesh Kumar Mishra, Rakesh Maurya |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Peptic Administration Oral Pharmacology Pharmacognosy law.invention Rats Sprague-Dawley Sapindaceae law Drug Discovery medicine Animals Stomach Ulcer Omeprazole biology Aspirin Dose-Response Relationship Drug Ethanol Chemistry Plant Extracts Stomach biology.organism_classification Anti-Ulcer Agents Rats Cold Temperature Plant Leaves Dose–response relationship Sucralfate Disease Models Animal Mucus medicine.anatomical_structure Biochemistry Allophylus Gastric Mucosa Solvents Female Phytotherapy medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 99(3) |
| ISSN: | 0378-8741 |
| Popis: | Allophylus serratus is known to possess various therapeutic properties. We evaluated the anti-ulcerogenic property of crude ethanolic extract of Allophylus serratus (AS) in different ulcer models in Sprague-Dawley rats. The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71.28, 62.50, 90.84 and 64.29% protection, respectively whereas, standard drug omeprazole (OMZ, 10mg/kg body weight) has shown protection index of 85.70, 74.99 and 74.99 in CRU, ASA and PL model respectively. Sucralfate (SUC, 500 mg/kg body weight) as a standard drug in AL model has 93.20% protection. Furthermore, AS has significantly decreased the free acidity (72.41%), total acidity (47.97%) and peptic activity (24.59%), respectively as well as has significantly increased the mucus secretion (29.41%). Conclusively the ulcer protective effect of AS may be due to its anti-secretory along with cytoprotective mechanism. |
| Databáze: | OpenAIRE |
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