The Use of Lanreotide in Polycystic Kidney Disease: A Single-Centre Experience
| Autor: | B Guillaume, S Treille, F Dehout, J Van Cauter, J M Bailly |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Published online: February 2014 business.industry Cilium Urology Lanreotide Renal function Kidney Volume Somatostatin analogues medicine.disease Polycystic kidney disease treatment Single centre chemistry.chemical_compound Somatostatin chemistry Nephrology Nephromegaly Polycystic kidney disease medicine medicine.symptom business |
| Zdroj: | Case Reports in Nephrology and Urology |
| ISSN: | 2296-9705 |
| DOI: | 10.1159/000358268 |
| Popis: | The secretion of large volumes of fluid into cysts and changes in the structure and mobility of the cilia of the renal tubular epithelium can lead to nephromegaly. This in turn often causes a deterioration of kidney function and arterial hypertension. In recent clinical studies, somatostatin analogues have demonstrated efficacy in isolated polycystic liver disease and, to a lesser extent, in polycystic kidney disease. Since the publication of these clinical studies, several patients have been referred to us for somatostatin analogue treatment. Here, we report our experience with 6 patients who were treated with lanreotide autogel 120 mg every 4 weeks over 6, 12 or 18 months and were longitudinally followed using CT scans without contrast agents, to evaluate the total bilateral kidney volume. We observed a mean decrease in volume of 4%, with mild to moderate side effects. |
| Databáze: | OpenAIRE |
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