The total incidence of loco-regional recurrence in a randomized trial of breast cancer TNM stage II. The South Sweden Breast Cancer Trial
| Autor: | T. Landberg, Ingrid Tengrup, Lena Tennvall-Nittby |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Antineoplastic Agents Breast Neoplasms law.invention Breast cancer Mastectomy Modified Radical Randomized controlled trial law medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Staging business.industry Incidence (epidemiology) Incidence Remission Induction Hematology General Medicine medicine.disease Combined Modality Therapy Surgery Clinical trial Radiation therapy Postmenopause Oncology Premenopause Female Hormone therapy Neoplasm Recurrence Local business Mastectomy Tamoxifen medicine.drug Follow-Up Studies |
| Zdroj: | Acta oncologica (Stockholm, Sweden). 32(6) |
| ISSN: | 0284-186X |
| Popis: | We studied loco-regional recurrence during follow-up (median observation time 8 years) in 1,153 patients, who underwent modified mastectomy and were randomly assigned to one of the following postoperative treatments; Premenopausal patients: radiotherapy, cyclophosphamide, or both; Post-menopausal patients: radiotherapy, tamoxifen, or both. Recurrence occurred in a total of 419 patients, 123 of whom had loco-regional recurrence with or without distant metastasis. The loco-regional recurrence rate was 7% in the irradiated subgroups and 17% in the non-irradiated subgroups, the corresponding cure rates being 43% and 58%. Complete remission of all local recurrence was obtained after the first treatment in 67% of the cases, and was persistent in 67% of them (44% overall). Complete remission was obtained in all patients with local recurrence who received local treatment only, and was persistent in 65%. Of local recurrences treated with a combination of surgery, radiotherapy and hormone therapy, complete response was obtained in 94% of the patients, and was persistent in 94% of them (88% overall). Complete remission of all regional recurrence was obtained after the first treatment in 58% of the patients and was persistent in 67% of them (39% overall). Postoperative radiotherapy reduced not only the total number of loco-regional recurrences but also the number of uncontrolled loco-regional recurrences. Aggressive local treatment would appear to yield both satisfactory initial control and, when combined with the hormone therapy, a high rate of persistent loco-regional control. |
| Databáze: | OpenAIRE |
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